Gene
|
HTR2B |
Protein
|
5-hydroxytryptamine receptor 2B |
Uniprot ID
|
P41595 |
Function
|
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down- stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5- hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine. |
Tissue Specificity
|
Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex. |
Sub-cellular localization
|
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome . |
Sequence Similarities
|
Belongs to the G-protein coupled receptor 1 family. |
Aliases
|
5 HT 2B antibody|5 HT 2B receptor antibody|5 HT(2B) antibody|5 HT2B antibody|5 hydroxytryptamine (serotonin) receptor 2B antibody|5 hydroxytryptamine (serotonin) receptor 2B G protein coupled antibody|5 hydroxytryptamine 2B receptor antibody|5 hydroxytryptamine receptor 2B antibody|5-HT-2B antibody|5-HT2B antibody|5-hydroxytryptamine receptor 2B antibody|5HT(2B) antibody|5HT2B_HUMAN antibody| 5HT2F antibody|Htr 2b antibody|Htr2b antibody|NP75 protein antibody|SEROTONIN 5HT2B RECEPTOR antibody|Serotonin receptor 2B antibody| Stomach fundus serotonin receptor antibody |
