Gene
|
AHR |
Protein
|
Aryl hydrocarbon receptor |
Uniprot ID
|
P30561 |
Function
|
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. |
Tissue Specificity
|
Expressed in all tissues tested including brain, heart, kidney, liver, lung, muscle, ovary, skin, spleen and thymus. |
Sub-cellular localization
|
Cytoplasm. Nucleus. Note: Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. |
Sequence Similarities
|
Contains 1 bHLH (basic helix-loop-helix) domain. |
Aliases
|
Ah receptor antibody|AHR antibody|AHR_HUMAN antibody|Aromatic hydrocarbon receptor antibody|Aryl hydrocarbon receptor antibody|Aryl hydrocarbon receptor precursor antibody| bHLHe76 antibody|Class E basic helix loop helix protein 76 antibody|Class E basic helix-loop-helix protein 76 antibody|HGNC:348 antibody |
